Cytotoxicity and Anticancer activity of Aqueous Leaf Extract of Solanum torvum on Normal Vero and Human Breast Adenocarcinoma MCF-7 Cell Line

Authors

  • Shanthi Dhamodaran Post Graduate and Research Department of Zoology, Dr Ambedkar Government Arts College, Vyasarpadi, Chennai 600039,Tamil Nadu, India
  • Raja Kothandam Post Graduate and Research Department of Zoology, Dr Ambedkar Government Arts College, Vyasarpadi, Chennai 600039,Tamil Nadu, India
  • Saravanan Ramachandran Post Graduate and Research Department of Zoology, Dr Ambedkar Government Arts College, Vyasarpadi, Chennai 600039,Tamil Nadu, India

DOI:

https://doi.org/10.35652/IGJPS.2022.12016

Keywords:

Solanum torvum leaves, Phytochemical analysis, Normal Vero cell line, Human breast adenocarcinoma cell line, Cell proliferation studies, Tryphan Blue, Selectivity index

Abstract

Natural herbal products are formulated with a combination of phytoconstituents from plants which play a pivotal role because of their diverse medicinal properties. Limited plants have been screened for their complete biological and pharmacological nature. In the present research work an attempt was made to infer the medicinal value of aqueous extract of Solanum torvum (S. torvum) leaves. Phytochemical analysis of the aqueous extracts of S. torvum leaf in the present study ascertain the presence of flavonoids, phenols, saponins, alkaloids, coumarins, sterols, proteins and reducing sugars. Further, the potentiality of aqueous extract of S. torvum leaves was assessed for its cytotoxic effect on Normal Vero cell line and anticancer activity on Human breast adenocarcinoma cell line by 3- (4, 5 dimethyl thiazole-2-yl) -2, 5-diphenyl tetrazolium bromide assay. A 24-hour incubation cell proliferation study reduced the cell viability of MCF-7 breast cancer cell lines. In vitro studies on cytotoxicity analysis on Vero cell line revealed that the aqueous leaf extract of S. torvum has no toxicity and further it was found to be effective in the prevention of cell proliferation by MCF-7 cell lines. © 2022 iGlobal Research and Publishing Foundation. All rights reserved.

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Published

2022-02-20

How to Cite

Dhamodaran, S., Kothandam, R., & Ramachandran, S. (2022). Cytotoxicity and Anticancer activity of Aqueous Leaf Extract of Solanum torvum on Normal Vero and Human Breast Adenocarcinoma MCF-7 Cell Line. Indo Global Journal of Pharmaceutical Sciences (IGJPS), 12, 145–152. https://doi.org/10.35652/IGJPS.2022.12016

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