https://igjps.com/index.php/IGJPS/issue/feed 2025-07-26T07:35:54+00:00 Open Journal Systems <p>IGJPS is an international journal online. It is interdisciplinary and aims to bring together different approaches for a diverse readership all over the world in pharmaceutical sciences. This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmacy and pharmaceutical sciences (Pharmaceutical Technology, Pharmacognosy, Natural Product Research, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal.</p> https://igjps.com/index.php/IGJPS/article/view/426 2025-05-19T02:24:31+00:00 Radha Singh radha@maharishiayurveda.global Nidhi Kaushik drnidhi@maharishiayurveda.global Rini Vohra dr.rini@maharishiayurveda.global Richa Shrivastava dr.richa@ayurveda.nl

<p>Background: Maharishi Amrit Kalash (MAK) is a polyherbal formulation of Ayurveda with potential immunomodulatory properties. While previous studies have explored its effects, the overall evidence base remains fragmented and inconclusive. This scoping review aims to map the existing literature on MAK, identify research gaps, and inform future research directions to elucidate its potential role in the immune system.</p> <p>Objective: This scoping review aims to comprehensively identify gaps in current understanding and methodically survey the existing literature on the immunomodulatory effects of Maharishi Amrit Kalash (MAK) through a synthesis of preclinical and clinical studies to provide direction for future research.</p> <p>Methods: Following PRISMA guidelines, a systematic search of relevant databases was conducted to identify studies investigating MAK's impact on immune function. Inclusion criteria encompassed preclinical and clinical studies evaluating MAK's effects on lymphoproliferative response, and other relevant immune parameters. While research published in other language than English, new reports, unpublished reports were excluded. </p> <p>Results: A total of 81 studies were found eligible to be reviewed. Out of which only 11 fulfilled the inclusion criteria. Preclinical studies, particularly in murine models, demonstrated enhanced macrophage activity, splenic lymphocyte proliferation, and cytokine production following MAK administration. Clinical trials, including a prospective double-blind, placebo-controlled trial and a study involving 500 individuals, revealed promising outcomes such as significant reductions in allergy symptom scores and improvements in overall well-being, as well as a reduced incidence of colds in the MAK group compared to controls.</p> <p>Discussion: MAK comes under Rasayana category is recognized for its immunomodulatory properties published in several journals. The preclinical and clinical studies showed that it has promising role in enhancing the macrophage function and lymphoproliferative response that boosts the immunity. Its use over 38 years in several countries also validated its safety and efficacy as an immunomodulatory agent.</p> <p>Conclusion: The findings of this scoping review highlight the potential of Maharishi Amrit Kalash as an immunomodulatory agent in traditional Ayurvedic medicine. However, further investigation through extensive randomized clinical trials is warranted to conclusively establish its efficacy and safety profile. This review underscores the importance of exploring MAK's immunomodulatory effects in depth to inform clinical practice and public health strategies. © 2024 Caproslaxy Media. All rights reserved.</p>

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