Drosophila melanogaster: A Platform to Study Therapeutic Neuromodulating Interventions

Ruchi Sharma; Rohit Sharma

doi:10.35652/IGJPS.2023.13003

Authors

Ruchi Sharma Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh 221005, India
Rohit Sharma Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh 221005, India

DOI:

https://doi.org/10.35652/IGJPS.2023.13003

Keywords:

Drosophila melanogaster, Neuromodulator, neurotransmitter, Dopamine, Octopamine, neuropeptide, astrocytes

Abstract

The Drosophila melanogaster (fruit fly), is a crucial and straightforward model organism for researching how genetic changes affect behavior and neural activity. Drosophila is used by biologists to study the nervous system because of its genetic tractability, well-known complex behaviors, straightforward neuroanatomy, and numerous human genes orthologs. Due to the Drosophila central nervous system's diminutive size, neurochemical studies are difficult. Recently, electrochemistry-based techniques have been created to monitor the release and clearance of neurotransmitters in real time in both larvae and adults. So, in this study Drosophila models used to study neuromodulator activity were reviewed and compiled using various databases. It is possible to take a close look at the functional role of traditional neuromodulators like octopamine, serotonin, dopamine, and neuropeptides using the genetic toolkit of Drosophila. This study compiles neurotransmitter role such as dopamine, serotonin, and octopamine production in both genetically normal and mutant flies. The fly is a system that is well-suited to shed new light on the complex issue of how neuromodulation might link behavioral demands particular to a given scenario with the level of arousal in the brain. The fly has powerful genetic tools and increasingly well-defined behavioral circuits.

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