Monkeypox - An Overview of Transmission, Clinical Manifestations and Treatment Approaches
DOI:
https://doi.org/10.35652/IGJPS.2022.12036Keywords:
Monkeypox, viral disease, Zoonotic, pathogenesis, Vaccination, antiviralsAbstract
Monkeypox (MPX) is a zoonotic viral disease with symptoms like smallpox but less clinical severity. It is an enveloped double-stranded DNA virus that belongs to the Orthopoxvirus genus of the Poxviridae family. Monkeypox is usually a self-limited disease with symptoms lasting from 2 to 4 weeks. However, the extent to which asymptomatic infection occurs is unknown. Since humans are not the causative organism of the monkeypox virus, rodents and primates are the most likely sources of the virus' transmission to humans. Crowded living quarters, poor hygiene, discontinuation of the smallpox vaccination, and decreased herd immunity are implicated in the human-to-human transmission of a disease that earlier was thought to be transmitted via animal contacts. Further, there are high similarities between this disease and smallpox in their pathogenesis except for the mode of viral entries. Due to inconsistencies in the epidemiological investigations, precise and adequate information regarding the virulence and transmissibility of the human monkeypox illness is scarce. Although smallpox vaccinations are believed to be efficacious against monkeypox, there are no known therapies for monkeypox infection that have been experimentally shown. However, the access to the vaccination must be carried out in a collaborative approach between the researchers and health authorities to ascertain the need to enable scale-up for their capacity to curb this infectious illness. © 2022 Caproslaxy Media. All rights reserved.
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References
Al-Tammemi AB, Albakri R, Alabsi S. The outbreak of human Monkeypox in 2022: A changing epidemiology or an impending aftereffect of smallpox eradication? Frontiers in Tropical Diseases. 2022;3. https://doi.org/10.3389/fitd.2022.951380
Andrei G, Fiten P, Krečmerová M, Opdenakker G, Topalis D, Snoeck R. Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance. Biomedicines. 2022;10(3):580. https://doi.org/10.3390%2Fbiomedicines10030580
Andrei G, Snoeck R. Cidofovir Activity against Poxvirus Infections. Viruses. 2010;2(12):2803-2830. https://doi.org/10.3390/v2122803
Bunge EM, Hoet B, Chen L, et al. The changing epidemiology of human monkeypox-A potential threat? A systematic review. PLoS Negl Trop Dis. 2022;16(2):e0010141. https://doi.org/10.1371/journal.pntd.0010141
Burrell CJ, Howard CR, Murphy FA. Epidemiology of Viral Infections. Fenner and White's Medical Virology. 2017;185-203. https://doi.org/10.1016/B978-0-12-375156-0.00013-8
Centers for Disease Control and Prevention. Clinical considerations for Monkeypox in children and adolescents. Centers for Disease Control and Prevention. 2022d. Retrieved August 16, 2022, from https://www.cdc.gov/poxvirus/monkeypox/clinicians/pediatric.html
Centers for Disease Control and Prevention. How it spreads. Centers for Disease Control and Prevention. 2022a. Retrieved August 14, 2022, from https://www.cdc.gov/poxvirus/monkeypox/transmission.html
Centers for Disease Control and Prevention. Interim clinical considerations for use of JYNNEOS and Acam2000 vaccines during the 2022 U.S. monkeypox outbreak. 2022b; Centers for Disease Control and Prevention. Retrieved August 17, 2022, from https://www.cdc.gov/poxvirus/monkeypox/considerations-for-monkeypox-vaccination.html
Centers for Disease Control and Prevention. Treatment information for healthcare professionals. Centers for Disease Control and Prevention. 2022c . Retrieved August 16, 2022, from https://www.cdc.gov/poxvirus/monkeypox/clinicians/treatment.html
Chauhan, RP, Dessie, ZG, Noreddin A, El Zowalaty ME. Systematic Review of Important Viral Diseases in Africa in Light of the 'One Health' Concept. Pathogens (Basel, Switzerland) 2020; 9(4), 301. https://doi.org/10.3390/pathogens9040301
Chen N, Li G, Liszewski MK, et al. Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology. 2005;340(1):46-63. https://doi.org/10.1016/j.virol.2005.05.030
Cohen, J. Monkeypox outbreak questions intensify as cases soar - Science. 2022 Retrieved August 14, 2022, from https://www.science.org/content/article/monkeypox-outbreak-questions-intensify-cases-soar
Di Giulio DB, Eckburg PB. Human monkeypox: an emerging zoonosis [published correction appears in Lancet Infect Dis. 2004 Apr;4(4):251]. Lancet Infect Dis. 2004;4(1):15-25. https://doi.org/10.1016/s1473-3099(03)00856-9
Dubey AK, Singh A, Prakash S, Kumar M, Singh AK. Race to arsenal COVID-19 therapeutics: Current alarming status and future directions. Chem Biol Interact. 2020; 332:109298. https://doi.org/10.1016/j.cbi.2020.109298
Farahat RA, Abdelaal A, Shah J, et al. Monkeypox outbreaks during COVID-19 pandemic: are we looking at an independent phenomenon or an overlapping pandemic? Ann Clin Microbiol Antimicrob. 2022;21(1):26... https://doi.org/10.1186/s12941-022-00518-2
Fenner F. Wallace P. Rowe lecture. Poxviruses of laboratory animals. Laboratory animal science, 1990; 40(5), 469–480.
Fox JG, Otto G, Colby LA. Selected Zoonoses. Laboratory Animal Medicine. 2015;1313-1370. https://doi.org/10.1016/B978-0-12-409527-4.00028-6
Guarner J, Johnson BJ, Paddock CD, et al. Monkeypox transmission and pathogenesis in prairie dogs. Emerg Infect Dis. 2004;10(3):426-431. https://doi.org/10.3201/eid1003.030878
Guidelines for management of Monkeypox Disease. Retrieved August 14, 2022, from https://main.mohfw.gov.in/sites/default/files/Guidelines%20for%20Management%20of%20Monkeypox%20Disease.pdf
Haller SL, Peng C, McFadden G, Rothenburg S. Poxviruses and the evolution of host range and virulence. Infect Genet Evol. 2014; 21:15-40. https://doi.org/10.1016/j.meegid.2013.10.014
Hammarlund E, Lewis MW, Carter SV, et al. Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox. Nat Med. 2005;11(9):1005-1011. https://doi.org/10.1038/nm1273
Harris E. What to Know About Monkeypox. JAMA, 2022; 327(23), 2278–2279. https://doi.org/10.1001/jama.2022.9499
Huggins J, Goff A, Hensley L, et al. Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. Antimicrob Agents Chemother. 2009;53(6):2620-2625. https://doi.org/10.1128/AAC.00021-09
Hughes LJ, Goldstein J, Pohl J, et al. A highly specific monoclonal antibody against monkeypox virus detects the heparin binding domain of A27. Virology. 2014;464-465:264-273. https://doi.org/10.1016/j.virol.2014.06.039
Jezek Z, Gromyko AI, Szczeniowski MV. Human monkeypox. Journal of Hygiene, Epidemiology, Microbiology, and Immunology. 1983 ;27(1):13-28.
Kaler J, Hussain A, Flores G, Kheiri S, Desrosiers D. Monkeypox: A Comprehensive Review of Transmission, Pathogenesis, and Manifestation. Cureus. 2022;14(7):e26531. https://doi.org/10.7759%2Fcureus.26531
Ladnyj ID, Ziegler P, Kima E. A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo. Bull World Health Organ. 1972;46(5):593-597.
Li Y, Olson VA, Laue T, Laker MT, Damon IK. Detection of monkeypox virus with real-time PCR assays. J Clin Virol. 2006;36(3):194-203. https://doi.org/10.1016/j.jcv.2006.03.012
Ligon BL. Monkeypox: a review of the history and emergence in the Western hemisphere. Semin Pediatr Infect Dis. 2004;15(4):280-287. https://doi.org/10.1053/j.spid.2004.09.001
Likos AM, Sammons SA, Olson VA, et al. A tale of two clades: monkeypox viruses. J Gen Virol. 2005;86(Pt 10):2661-2672. https://doi.org/10.1099/vir.0.81215-0
Mascarenhas A. Experts: Surveillance of monkeypox cases can be strengthened by screening at-risk groups. MSN. https://www.msn.com/en-in/lifestyle/other/experts-surveillance-of-monkeypox-cases-can-be-strengthened-by-screening-at-risk-groups/ar-AA11Cr3K. 2022. Accessed September 22, 2022.
McCollum AM, Damon IK. Human monkeypox [published correction appears in Clin Infect Dis. 2014 Jun;58(12):1792]. Clin Infect Dis. 2014;58(2):260-267. https://doi.org/10.1093/cid/cit703
Meyer H, Perrichot M, Stemmler M, et al. Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001. J Clin Microbiol. 2002;40(8):2919-2921. https://doi.org/10.1128%2FJCM.40.8.2919-2921.2002
Mohapatra RK, Tuli HS, Sarangi AK, et al. Unexpected sudden rise of human monkeypox cases in multiple non-endemic countries amid COVID-19 pandemic and salient counteracting strategies: Another potential global threat? Int J Surg. 2022; 103:106705. https://doi.org/10.1016%2Fj.ijsu.2022.106705
Nalca A, Rimoin AW, Bavari S, Whitehouse CA. Reemergence of monkeypox: prevalence, diagnostics, and countermeasures. Clin Infect Dis. 2005;41(12):1765-1771. https://doi.org/10.1086/498155
Parker S, Buller RM. A review of experimental and natural infections of animals with monkeypox virus between 1958 and 2012. Future Virol. 2013;8(2):129-157. https://doi.org/10.2217/fvl.12.130
Peiró-Mestres A, Fuertes I, Camprubí-Ferrer D, et al. Frequent detection of monkeypox virus DNA in saliva, semen, and other clinical samples from 12 patients, Barcelona, Spain, May to June 2022. Euro Surveill. 2022;27(28):2200503. https://doi.org/10.2807/1560-7917.ES.2022.27.28.2200503
Rimoin AW, Mulembakani PM, Johnston SC, et al. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci U S A. 2010;107(37):16262-16267.. https://doi.org/10.1073/pnas.1005769107
Rojek, A., Dunning, J., Olliaro, P. Monkeypox: How will we know if the treatments work? The Lancet Infectious Diseases 2022. https://doi.org/10.1016/s1473-3099(22)00514-x
Shchelkunov SN, Totmenin AV, Safronov PF, et al. Analysis of the monkeypox virus genome. Virology. 2002;297(2):172-194. https://doi.org/10.1006/viro.2002.1446
Shete AM, Yadav PD, Kumar A, et al. Genome characterization of monkeypox cases detected in India: Identification of three sub clusters among A.2 lineage. bioRxiv; 2022. https://doi.org/10.1101/2022.09.16.507742
Siegrist EA, Sassine J. Antivirals with Activity Against Monkeypox: A Clinically Oriented Review. Clin Infect Dis. 2022; ciac622. https://doi.org/10.1093/cid/ciac622
Singla, RK, Singla S, Shen B. Biased studies and sampling from LGBTQ communities created a next-level social stigma in Monkeypox: A public health emergency of international concern (PHEIC). Indo Global Journal of Pharmaceutical Sciences 2022; 12, 205–208. https://doi.org/10.35652/igjps.2022.12025
Sklenovská N, Van Ranst M. Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans. Front Public Health. 2018; 6:241. https://doi.org/10.3389/fpubh.2018.00241
Sklenovská, N. Monkeypox Virus. In: Malik, Y.S., Singh, R.K., Dhama, K. (eds) Animal-Origin Viral Zoonoses. Livestock Diseases and Management. 2020; Springer, Singapore. https://doi.org/10.1007/978-981-15-2651-0_2
Stagles MJ, Watson AA, Boyd JF, More IA, McSeveney D. The histopathology and electron microscopy of a human monkeypox lesion. Trans R Soc Trop Med Hyg. 1985;79(2):192-202. https://doi.org/10.1016/0035-9203(85)90333-5
Stern D, Olson VA, Smith SK, et al. Rapid and sensitive point-of-care detection of Orthopoxviruses by ABICAP immunofiltration. Virol J. 2016;13(1):207. https://doi.org/10.1186/s12985-016-0665-5
Stittelaar KJ, Neyts J, Naesens L, et al. Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. Nature. 2006;439(7077):745-748. https://doi.org/10.1038/nature04295
Thornhill JP, Barkati S, Walmsley S, et al. Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022. N Engl J Med. 2022;387(8):679-691. https://doi.org/10.1056/NEJMoa2207323
Tiecco G, Degli Antoni M, Storti S, Tomasoni LR, Castelli F, Quiros-Roldan E. Monkeypox, a literature review: What is new and where does this concerning virus come from? Viruses. 2022;14(9):1894. https://doi.org/10.3390/v14091894
Townsend MB, MacNeil A, Reynolds MG, et al. Evaluation of the Tetracore Orthopox BioThreat® antigen detection assay using laboratory grown orthopoxviruses and rash illness clinical specimens. J Virol Methods. 2013;187(1):37-42. https://doi.org/10.1016/j.jviromet.2012.08.023
Tulchinsky TH, Varavikova EA. Communicable Diseases. The New Public Health. 2014;149-236. https://doi.org/10.1016/B978-0-12-415766-8.00004-5
Wachtman L, Mansfield K. Viral Diseases of Nonhuman Primates. Nonhuman Primates in Biomedical Research. 2012;1-104. https://doi.org/10.1016/B978-0-12-381366-4.00001-8
Wachtman L, Mansfield K. Viral Diseases of Nonhuman Primates. Nonhuman Primates in Biomedical Research. 2012;1-104. https://doi.org/10.1016/b978-0-12-381366-4.00001-8
Weaver JR, Isaacs SN. Monkeypox virus and insights into its immunomodulatory proteins. Immunol Rev. 2008; 225:96-113. https://doi.org/10.1111/j.1600-065X.2008.00691.x
World Health Organization. Monkeypox. World Health Organization. 2022 Retrieved August 16, 2022, from https://www.who.int/news-room/fact-sheets/detail/monkeypox
Xiao SY, Sbrana E, Watts DM, Siirin M, da Rosa AP, Tesh RB. Experimental infection of prairie dogs with monkeypox virus. Emerg Infect Dis. 2005;11(4):539-545. https://doi.org/10.3201/eid1104.040907