A Virulent Disease Called Monkeypox: A Case Report of Countries in Africa Where The Disease is Endemic

Authors

  • Michael P. Okoh Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China https://orcid.org/0000-0002-2438-8500
  • Kenneth C. Nwachukwu Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Abuja, P.M.B 117 FCT, Abuja-Nigeria

DOI:

https://doi.org/10.35652/IGJPS.2022.12030

Keywords:

Monkeypox, Smallpox, Sexually transmitted disease, COVID-19, Viruses, Vaccination, Zoonotic

Abstract

Cases of Monkeypox continue to rise and the World Health Organization (WHO), declared it a public health emergency of international concern (PHEIC). A virus called monkey pox causes the disease and it is zoonotic. The epidemiological surveillance from 1981-1986 in the Democratic Republic of Congo (DRC) a country in Africa were the disease is endemic, documented only 338 cases. Previously, 90% of the affected persons were children approximately 15 years of age at least in the endemic countries in Africa. Beyond Africa, 99%  cases of the current outbreak were found in men and of those, 98% involved men who have sex with men implying it is being transmitted through sexual activities. Crowded living quarters, poor hygiene, discontinuation of the smallpox vaccination, amongst others were implicated in the human to human transmission. The symptoms of the disease includes, viremia with 1-2 days of  fever and lymphadenopathy before lesions appear. Patients at this stage may be contagious. For treatments, there are no known clinically proven treatments for the disease. Polymerase chain reaction (PCR) amplification are used for specific diagnosis and smallpox vaccines are effective against the disease. Table 1 shows cases from Africa union member countries (AUMC), and Congo Republic, Cameroon and DRC, have a high cumulative frequency (CFR) of occurrence (43, 5.6 and 4.1%), respectively (see Fig 2). The vaccine is not readily available in these endemic countries thus, donors countries needs to collaborate with researchers and health officials to determine what these endemic countries in the global south requires towards enabling scale up in response to this disease.  © 2022 iGlobal Research and Publishing Foundation. All rights reserved.

Metrics

Metrics Loading ...

References

World Health Organization. Monkeypox. Available from: https://www.who.int/news-room/questions-and-answers/item/monkeypox?gclid=Cj0KCQjworiXBhDJARIsAMuzAuyi8nSAeuIxHh7DUZsZmv15JpuYWP_XHRRpgbKt8hywzUD4agoJAKAaAsMwEALw_wcB. 2022 Aug 04. Accessed: 2022 Aug 07

Mary, B.G., William, D.J., Monkey pox. Available from: https://emedicine.medscape.com/article/1134714-overview#a5. 2022 29: Accessed 2022 Aug 07

"Multi-country monkeypox outbreak in non-endemic countries" (https://www.who.int/emergencies/disease-outbre ak-news/item/2022-DON385) . World Health Organization. 21 May 2022. Archived (https://web.archive.org/web/ 20220522002241/https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON385) from the original on 22 May 2022. Retrieved 25 May 2022.

"So, Have You Heard About Monkeypox?" (https://www.theatlantic.com/health/archive/2022/05/monkeypox-outb reak-covid-pandemic/629920/) . The Atlantic. 19 May 2022. Archived (https://web.archive.org/web/2022062312 2621/https://www.theatlantic.com/health/archive/2022/05/monkeypox-outbreak-covid-pandemic/629920/) from the original on 23 June 2022. Retrieved 2 June 2022.

"Monkeypox – United Kingdom of Great Britain and Northern Ireland" (https://www.who.int/emergencies/disease- outbreak-news/item/2022-DON381) . World Health Organization. 16 May 2022. Archived (https://web.archive.or g/web/20220517223855/https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON381) from the original on 17 May 2022. Retrieved 17 May 2022.

"5 cases of monkeypox confirmed in Ghana" (https://www.myjoyonline.com/5-cases-of-monkeypox-confirmed-in-ghana/) . MyJoyOnline.com. Archived (https://web.archive.org/web/20220621191942/https://www.myjoyonlin e.com/5-cases-of-monkeypox-confirmed-in-ghana/) from the original on 21 June 2022. Retrieved 8 June 2022.

Grover, N., Revill, J., Rigby, J. "WHO declares global health emergency over monkeypox outbreak" (https://www.reuters.com/business/healthcare-pharmaceuticals/monkeypox-outbreak-con stitutes-global-health-emergency-who-2022-07-23/) . Reuters. Retrieved 23 July 2022.

Davis, N. "Monkeypox declared global health emergency by WHO as cases surge" (https://www.theguardian.com/world/2022/jul/23/monkeypox-who-declares-public-health-emergency-of-international-conc ern) . The Guardian. Retrieved 23 July 2022.

"Monkeypox Data Explorer" (https://ourworldindata.org/explorers/monkeypox?tab=table&time=2022-05-24..latest &facet=none&Metric=Confirmed+cases&Frequency=Cumulative&Shown+by=Date+of+confirmation&country=~O WID_WRL) . OurWorldInData. Archived (https://web.archive.org/web/20220628125406/https://ourworldindata.o rg/explorers/monkeypox?tab=table&time=2022-05-24. latest&facet=none&Metric=Confirmed+cases&Frequency= Cumulative&Shown+by=Date+of+confirmation&country=~OWID_WRL) from the original on 28 June 2022. Retrieved 27 May 2022.

Kozlov, M. "Monkeypox declared a global emergency: will it help contain the outbreak?" (https:// www.nature.com/articles/d41586-022-02054-7) . Nature. doi:10.1038/d41586-022-02054-7 (https://doi.org/10. 1038%2Fd41586-022-02054-7) .

Marlyn, J.M,, Balram, R., Farah, Z. Monkeypox. National Library of Medicine. Available from: https://www.ncbi.nlm.nih.gov/books/NBK574519/. 2022 Jul 16. Accessed: 2022 Aug 07

Hutin, Y.J. et al., Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. Emerg Infect Dis. 2001 May-Jun. 7(3):434-8. Available from: https://read.qxmd.com/read/11384521/outbreak-of-human-monkeypox-democratic-republic-of-congo-1996-to-1997

Stanford University, cited Aug 17 2022. Available from: https://virus.stanford.edu/pox/2000/monkeypox_virus.html#:~:text=The%20pathogenesis%20of%20human%20monkeypox,person%2Dto%2Dperson%20transmission.

2022 United States Monkeypox Response and Recommendations. Centers for Disease Control and Prevention. Available from: https://www.cdc.gov/poxvirus/monkeypox/response/2022/index.html. 2022 July 28; Accessed: 2022 Aug 07.

Hutson, C, et al., Comparison of Monkeypox Virus Clade Kinetics and Pathology within the Prairie Dog Animal Model Using a Serial Sacrifice Study Design. Biomed Res Int. 2015;2015:965710. Available from: https://pubmed.ncbi.nlm.nih.gov/26380309

McCollum, A.M., Damon, I.K. Human monkeypox. Clin Infect Dis. 2014 Jan;58(2):260-7. Available from: https://pubmed.ncbi.nlm.nih.gov/24158414/

Weave,r J.R., Isaacs, S.N. Monkeypox virus and insights into its immunomodulatory proteins. Immunol Rev. 2008 Oct;225:96-113. Available from: https://pubmed.ncbi.nlm.nih.gov/18837778/

Monkeypox. Wkly Epidemiol Rec. 2011 Oct 07;86(41):448-51. Available from: https://pubmed.ncbi.nlm.nih.gov/21984986

Petersen, I., et al., . Vaccinating against monkeypox in the Democratic Republic of the Congo. Antiviral Res. 2019 Feb;162:171-177. Available from: https://pubmed.ncbi.nlm.nih.gov/30445121

Reynolds, M.G., et al., Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research. Viruses. 2017 Dec 12;9(12). Available from: https://pubmed.ncbi.nlm.nih.gov/29231870/

Jezek, Z., Fenner, F. Human monkeypox. Melnick JL, ed. Monographs in Virology. Basel, Switzerland: Karger. Vol 17: 1988.

Fine, P.E., Jezek, Z., Grab, B., Dixon, H. The transmission potential of monkeypox virus in human populations. Int J Epidemiol. 1988 Sep. 17(3):643-50. Available from: https://read.qxmd.com/read/2850277/the-transmission-potential-of-monkeypox-virus-in-human-populations

Cono, J., Casey, C.G., Bell, D.M. Smallpox vaccination and adverse reactions. Guidance for clinicians. MMWR Recomm Rep. 2003 Feb 21. 52:1-28. Available from: https://read.qxmd.com/read/12617510/smallpox-vaccination-and-adverse-reactions-guidance-for-clinicians

"2003 U.S. Outbreak Monkeypox" (https://www.cdc.gov/poxvirus/monkeypox/outbreak.html) . CDC. 11 May 2015. Archived(https://web.archive.org/web/20171015202731/https://www.cdc.gov/poxvirus/monkeypox/outbr eak.html) from the original on 15 October 2017. Retrieved 15 October 2017.

Kamsukom, N. "African Centre For Disease Control Alerts Cameroon On Monkeypox" (https://w ww.journalducameroun.com/en/african-centre-for-disease-control-alerts-cameroon-on-monkeypox/) . Journal du Cameroun. Archived (https://web.archive.org/web/20220527165842/https://www.journalducameroun.com/e n/african-centre-for-disease-control-alerts-cameroon-on-monkeypox/) from the original on 27 May 2022. Retrieved 27 May 2022.

Tomori, O. "Monkeypox in Nigeria: why the disease needs intense management" (https://theconversation.c om/monkeypox-in-nigeria-why-the-disease-needs-intense-management-165022) . The Conversation. Archived (h ttps://web.archive.org/web/20210725083905/http://theconversation.com/monkeypox-in-nigeria-why-the-disease- needs-intense-management-165022) from the original on 25 July 2021. Retrieved 25 May 2022.

Tomori, O. "Monkeypox is endemic in Nigeria. But surveillance isn't what it should be" (https://theconversat ion.com/monkeypox-is-endemic-in-nigeria-but-surveillance-isnt-what-it-should-be-183711). The Conversation. Archived (https://web.archive.org/web/20220525090451/http://theconversation.com/monkeypox-is-endemic-in-n igeria-but-surveillance-isnt-what-it-should-be-183711) from the original on 25 May 2022. Retrieved 25 May 2022.

Ileyemi, M. "Monkeypox: Nigeria records 558 cases, eight deaths in five years" (https://www. premiumtimesng.com/news/top-news/528825-monkeypox-nigeria-records-558-cases-eight-deaths-in-five-year s.html) . Premium Times. Archived (https://web.archive.org/web/20220510142341/https://www.premiumtimes ng.com/news/top-news/528825-monkeypox-nigeria-records-558-cases-eight-deaths-in-five-years.html) from the original on 10 May 2022. Retrieved 25 May 2022.

"Nigeria records first monkeypox death in 2022 as cases rise to 21" (https://www.thecable.ng/nigeria-records-first -monkeypox-death-in-2022-as-cases-rise-to-21) . TheCable. 30 May 2022. Archived (https://web.archive.org/we b/20220530145527/https://www.thecable.ng/nigeria-records-first-monkeypox-death-in-2022-as-cases-rise-to-2 1) from the original on 30 May 2022. Retrieved 26 June 2022.

"Second meeting of the International Health Regulations (2005) (IHR) Emergency Committee regarding the multi- country outbreak of monkeypox" (https://www.who.int/news/item/23-07-2022-second-meeting-of-the-internation al-health-regulations-(2005)-(ihr)-emergency-committee-regarding-the-multi-country-outbreak-of-monkeypox) (Statement). World Health Organization. 23 July 2022. Retrieved 23 July 2022.

"Multi-country monkeypox outbreak: situation update (10 June 2022)" (https://www.who.int/emergencies/disease -outbreak-news/item/2022-DON392) . World Health Organization. 10 June 2022. Archived (https://web.archive.o rg/web/20220614173509/https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON392) from the original on 14 June 2022. Retrieved 22 June 2022.

"Multi-country monkeypox outbreak: situation update (17 June 2022)" (https://www.who.int/emergencies/disease -outbreak-news/item/2022-DON393) . World Health Organization. 17 June 2022. Archived (https://web.archive.o rg/web/20220622005300/https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON393) from the original on 22 June 2022. Retrieved 22 June 2022.

"Weekly Bulletin on Outbreaks and Other Emergencies" (https://apps.who.int/iris/bitstream/handle/10665/35928 1/OEW27-270603072022.pdf) (PDF). WHO Africa. 3 July 2022. Retrieved 25 June 2022.

"Weekly Bulletin on Outbreaks and Other Emergencies" (https://apps.who.int/iris/bitstream/handle/10665/35661 9/OEW24-0612062022.pdf) (PDF). WHO Africa. 12 June 2022. Archived (https://web.archive.org/web/2022061 8133251/https://apps.who.int/iris/bitstream/handle/10665/356619/OEW24-0612062022.pdf) (PDF) from the original on 18 June 2022. Retrieved 25 June 2022.

"Liberia reports first monkeypox case since 2018" (https://www.reuters.com/world/africa/liberia-reports-first-mon keypox-case-since-2018-2022-07-25/) . Reuters. 25 July 2022. Retrieved 25 July 2022.

"Update on Monkeypox (MPX) in Nigeria, Epi-week: 24, June 19, 2022 – Nigeria | ReliefWeb" (https://reliefweb.int/ report/nigeria/update-monkeypox-mpx-nigeria-epi-week-24-june-19-2022). reliefweb.int. Archived (https://web.a rchive.org/web/20220626025342/https://reliefweb.int/report/nigeria/update-monkeypox-mpx-nigeria-epi-week-2 4-june-19-2022) from the original on 26 June 2022. Retrieved 26 June 2022.

Nigerian CDC National Monkeypox Public Health Response Guidelines -

https://ncdc.gov.ng/themes/common/docs/protocols/96_1577798337.pdf

US CDC - 2022 Monkeypox Outbreak Global Map | Monkeypox | Poxvirus | CDC

WHO - Multi-country monkeypox outbreak in non-endemic countries

Downloads

Published

2022-08-22

How to Cite

Okoh, M., & Nwachukwu, K. C. (2022). A Virulent Disease Called Monkeypox: A Case Report of Countries in Africa Where The Disease is Endemic. Indo Global Journal of Pharmaceutical Sciences, 12, 237–244. https://doi.org/10.35652/IGJPS.2022.12030